WARNINGS, DISCLAIMERS AND OTHER INTIMIDATING LEGAL STATEMENTS
First the FDA accepted and obligatory statements
RECOMMENDED
DOSE: One Capsule WEEKLY for adults.
WARNINGS: Not intended for children, pregnant women,
or persons with kidney disease, bone disease, malignancies, or calcium
disorders except upon the advice of and under the supervision of a physician. (In
fact, cholecalciferol is often recommended for some of the above situations.)
Side
effects from too much vitamin D may include persisting nausea, vomiting,
poor appetite, constipation, weakness and weight loss.
Toxicity
Vitamin D toxicity is not common and difficult
to achieve. This is because: 1) there are few natural dietary sources
of vitamin D and even usual fortified sources contain relatively small
amounts. 2) 25-OH cholecalciferol (the form stored by the body after
conversion in the liver) has only weak hormonal activity. (Again, vitamin
D is a hormone, not a vitamin.) The conversion to the active hormone,
1,25-OH cholecalciferol, is an internally regulated process.
Most recent
reported vitamin D toxicity has involved repeated ingestion over significant
periods of time of poorly compounded over the counter nutritional supplements:
Critique
of the Considerations for Establishing the Tolerable Upper Intake
Level for Vitamin D: Critical Need for Revision Upwards
Reinhold Vieth
American Society for Nutrition J. Nutr. 136:1117-1122,
April 2006
http://content.nejm.org/cgi/content/full/357/3/308
Vitamin
D Intoxication Associated with an Over-the-Counter Supplement
P.
Koutkia, T. C. Chen, and M. F. Holick - 5 Jul, 2001
http://content.nejm.org/cgi/content/full/345/1/66-
a?ijkey=cc079da10156cb4274319c9cac72bfa83fa13935&keytype2=tf_ipsecsha
Accidental over fortification of milk has been reported.
An outbreak of hypervitaminosis D associated with the overfortification
of milk from a home-delivery dairy.
S
Blank, K S Scanlon, T H Sinks, S Lett and H Falk
American
Journal of Public Health, Vol. 85, Issue 5 656-659 http://www.ajph.org/cgi/content/abstract/85/5/656
This,
although they are available, is why concentrated powders and liquid preparations
have been considered prescription products by the FDA.
PLEASE NOTE that each of our production lots is tested prior
to distribution. In addition annual testing is done for evidence of
contamination or degradation.
Recommended links for further reading include:
Critique of the Considerations
for Establishing the Tolerable Upper Intake Level for Vitamin D: Critical
Need for Revision Upwards
http://jn.nutrition.org/cgi/content/full/136/4/1117
Short- and Long-Term Safety of Weekly High-Dose Vitamin D3
Supplementation in School Children
http://jcem.endojournals.org/cgi/content/abstract/93/7/2693
Vitamin D Toxicity, Policy, and Science
Journal
of Bone and Mineral Research,
December 2007:22:V64-V68
Reinhold Vieth
http://www.jbmronline.org/doi/abs/10.1359/jbmr.07s221
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